Abstract |
The purpose of this study was to evaluate the antihypertensive effect of a new calcium antagonist, clentiazem, on inpatients or outpatients with essential hypertension. After blood pressure was stable and greater than 160/95 mmHg with placebo for at least a 2-week observation period, oral clentiazem was administered once daily and dosage was increased stepwise from 10 to 40 mg over 10 weeks. Blood pressure significantly decreased by the second week of the study, and this hypotensive effect was maintained until the eighth week. Cumulative effective rate (percent of patients whose blood pressure decreased in 20/10 mmHg) in 62 outpatients were as follows; 10.3% at 10 mg, 39.6% at 20 mg, 70.2% at 30 mg, 76.6% at 40 mg. There was no significant postural change observed in the blood pressure from supine to standing position. Side effects such as dizziness, general malaise and gait disturbances were observed in 3 (3.9%) of 76 patients. No abnormal changes in clinical laboratory examinations or electrocardiograms were caused by clentiazem. Thus these data demonstrated that clentiazem produces certain antihypertensive effects with sufficient safety.
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Authors | S Kawakita, M Kinoshita, H Ishikawa, T Kagoshima, R Katori, K Ishikawa, Y Hirota |
Journal | Clinical cardiology
(Clin Cardiol)
Vol. 14
Issue 1
Pg. 53-60
(Jan 1991)
ISSN: 0160-9289 [Print] United States |
PMID | 2019030
(Publication Type: Clinical Trial, Journal Article, Multicenter Study)
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Chemical References |
- Calcium Channel Blockers
- clentiazem
- Diltiazem
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Topics |
- Adult
- Aged
- Blood Pressure
- Calcium Channel Blockers
(adverse effects, therapeutic use)
- Diltiazem
(adverse effects, analogs & derivatives, pharmacology, therapeutic use)
- Drug Administration Schedule
- Drug Evaluation
- Female
- Heart Rate
- Humans
- Hypertension
(drug therapy, physiopathology)
- Male
- Middle Aged
- Pilot Projects
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