Abstract | BACKGROUND: MATERIALS AND METHODS: New Zealand White rabbits were subjected to sevoflurane PostC, oxygen (O(2)), or sham treatment at the onset of spinal cord reperfusion for 10 min. Spinal cord ischemia was induced by clamping the aorta both below the left renal artery and above the aortic bifurcation. Forty-eight hours after reperfusion, the motor function of the lower limbs was evaluated and the lumbar spinal cord segment (L5-7) was harvested for histopathologic and biochemical analyses in the presence or absence of N-2-mercaptopropionylglycine, a potent oxygen free radical scavenger. RESULTS: CONCLUSION:
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Authors | Qiang Wang, Qiong Chen, Qian Ding, Qianzi Yang, Ye Peng, Yan Lu, Jiao Deng, Lize Xiong |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 169
Issue 2
Pg. 292-300
(Aug 2011)
ISSN: 1095-8673 [Electronic] United States |
PMID | 20189594
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Antioxidants
- Free Radicals
- Methyl Ethers
- Platelet Aggregation Inhibitors
- Sevoflurane
- Catalase
- Superoxide Dismutase
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Topics |
- Animals
- Antioxidants
(metabolism)
- Aorta
(physiopathology)
- Catalase
(metabolism)
- Constriction
- Free Radicals
(metabolism)
- Ischemic Postconditioning
(methods)
- Male
- Methyl Ethers
(pharmacology, therapeutic use)
- Models, Animal
- Platelet Aggregation Inhibitors
(pharmacology, therapeutic use)
- Rabbits
- Reperfusion Injury
(metabolism, prevention & control)
- Sevoflurane
- Spinal Cord
(blood supply, metabolism)
- Superoxide Dismutase
(metabolism)
- Up-Regulation
(drug effects)
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