Abstract |
In attempts to substantiate the possible participation of reactive oxygen species, and the significance of the xanthine oxidase system in both post-ischaemic reperfusion necrosis of the island flap and distal necrosis of the pedicle flap, and to develop new pharmacological measures for salvaging flap necrosis, a series of experiments were made using an island flap model and a random-pattern flap model in rats. The results were as follows: (1) Epoxysuccinyl derivative (E-64c), allopurinol and L-SOD salvaged post-ischaemic reperfusion necrosis of the island flaps; (2) E-64c and allopurinol did not salvage anticipated necrosis of the distal region of random flaps but L-SOD did; (3) tissue SOD activity did not reflect the fate of the island flap, but did of the distal region of the random flap. These results demonstrated a possible involvement of ROS in both post-ischaemic necrosis of island flaps and distal necrosis of random flaps. However, xanthine oxidase was significant in producing ROS only in the former.
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Authors | S Suzuki, N Yoshioka, N Isshiki, H Hamanaka, Y Miyachi |
Journal | British journal of plastic surgery
(Br J Plast Surg)
1991 Feb-Mar
Vol. 44
Issue 2
Pg. 130-4
ISSN: 0007-1226 [Print] England |
PMID | 2018899
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Cysteine Proteinase Inhibitors
- Allopurinol
- N-(N-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine
- Superoxide Dismutase
- Xanthine Oxidase
- Leucine
- Oxygen
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Topics |
- Allopurinol
(therapeutic use)
- Animals
- Antioxidants
(therapeutic use)
- Cysteine Proteinase Inhibitors
(therapeutic use)
- Leucine
(analogs & derivatives, therapeutic use)
- Male
- Necrosis
(prevention & control)
- Oxygen
- Rats
- Rats, Inbred Strains
- Reperfusion Injury
(prevention & control)
- Skin
(enzymology)
- Superoxide Dismutase
(therapeutic use)
- Surgical Flaps
- Xanthine Oxidase
(metabolism)
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