HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Association of exposure to phthalates with endometriosis and uterine leiomyomata: findings from NHANES, 1999-2004.

AbstractBACKGROUND:
Phthalates are ubiquitous chemicals used in consumer products. Some phthalates are reproductive toxicants in experimental animals, but human data are limited.
OBJECTIVE:
We conducted a cross-sectional study of urinary phthalate metabolite concentrations in relation to self-reported history of endometriosis and uterine leiomyomata among 1,227 women 20-54 years of age from three cycles of the National Health and Nutrition Examination Survey (NHANES), 1999-2004.
METHODS:
We examined four phthalate metabolites: mono(2-ethylhexyl) phthalate (MEHP), monobutyl phthalate (MBP), monoethyl phthalate (MEP), and monobenzyl phthalate (MBzP). From the last two NHANES cycles, we also examined mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP). We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for potential confounders.
RESULTS:
Eighty-seven (7%) and 151 (12%) women reported diagnoses of endometriosis and leiomyomata, respectively. The ORs comparing the highest versus lowest three quartiles of urinary MBP were 1.36 (95% CI, 0.77-2.41) for endometriosis, 1.56 (95% CI, 0.93-2.61) for leiomyomata, and 1.71 (95% CI, 1.07-2.75) for both conditions combined. The corresponding ORs for MEHP were 0.44 (95% CI, 0.19-1.02) for endometriosis, 0.63 (95% CI, 0.35-1.12) for leiomyomata, and 0.59 (95% CI, 0.37-0.95) for both conditions combined. Findings for MEHHP and MEOHP agreed with findings for MEHP with respect to endometriosis only. We observed null associations for MEP and MBzP. Associations were similar when we excluded women diagnosed > 7 years before their NHANES evaluation.
CONCLUSION:
The positive associations for MBP and inverse associations for MEHP in relation to endometriosis and leiomyomata warrant investigation in prospective studies.
AuthorsJennifer Weuve, Russ Hauser, Antonia M Calafat, Stacey A Missmer, Lauren A Wise
JournalEnvironmental health perspectives (Environ Health Perspect) Vol. 118 Issue 6 Pg. 825-32 (Jun 2010) ISSN: 1552-9924 [Electronic] United States
PMID20185384 (Publication Type: Journal Article)
Chemical References
  • Environmental Pollutants
  • Phthalic Acids
  • phthalic acid
Topics
  • Adult
  • Cross-Sectional Studies
  • Endometriosis (chemically induced, epidemiology)
  • Environmental Exposure (analysis)
  • Environmental Pollutants (toxicity, urine)
  • Female
  • Humans
  • Leiomyoma (chemically induced, epidemiology)
  • Logistic Models
  • Middle Aged
  • Nutrition Surveys
  • Odds Ratio
  • Phthalic Acids (toxicity, urine)
  • Surveys and Questionnaires
  • United States
  • Uterine Neoplasms (chemically induced, epidemiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: