Evaluation of the anticancer activities of Tweens 20, 40 and 60 in SJL/J mice.

Abstract

Tween 20 (polyoxyethylenesorbitan monolaurate), Tween 40 (polyoxyethylenesorbitan monopalmitate), and Tween 60 (polyoxyethylenesorbitan monostearate) were found to have little activity against development of reticulum cell sarcoma in SJL/J mice. These findings resulted in studies to explain the previous observation that Tween 80 (polyoxyethylenesorbitan monooleate) has anticancer activity in the SJL/J tumor system. Evidence is presented to suggest that the apparent difference may be related to the fatty acid component (saturated or unsaturated) of the Tween.

• Authors: C G Crispens Jr, J R Sorenson
• Journal: Anticancer research (Anticancer Res) 1991 Jan-Feb Vol. 11 Issue 1 Pg. 407-8 ISSN: 0250-7005 [Print] Greece
• PMID: 2018377 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antineoplastic Agents
• Polysorbates
• polysorbate 40

Topics

• Animals
• Antineoplastic Agents
• Female
• Lymphoma, Large B-Cell, Diffuse (prevention & control)
• Mice
• Mice, Inbred Strains
• Polysorbates (therapeutic use)