Eph receptors and ephrins in cancer: bidirectional signalling and beyond.

Abstract

The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression patterns in cancer cells and tumour blood vessels, which suggest important roles for their bidirectional signals in many aspects of cancer development and progression. Eph gene mutations probably also contribute to cancer pathogenesis. Eph receptors and ephrins have been shown to affect the growth, migration and invasion of cancer cells in culture as well as tumour growth, invasiveness, angiogenesis and metastasis in vivo. However, Eph signalling activities in cancer seem to be complex, and are characterized by puzzling dichotomies. Nevertheless, the Eph receptors are promising new therapeutic targets in cancer.

• Authors: Elena B Pasquale
• Journal: Nature reviews. Cancer (Nat Rev Cancer) Vol. 10 Issue 3 Pg. 165-80 (Mar 2010) ISSN: 1474-1768 [Electronic] England
• PMID: 20179713 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)

Chemical References

• Ephrins
• Receptors, Eph Family

Topics

• Animals
• Ephrins (metabolism)
• Gene Expression Regulation, Neoplastic
• Humans
• Neoplasms (genetics, metabolism, pathology, physiopathology)
• Receptors, Eph Family (genetics, metabolism)
• Signal Transduction