Liver transplantation results for hepatocellular carcinoma in Chile.
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| Abstract | UNLABELLED:
Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver. Liver transplantation is the best treatment for HCC; it improves survival, cures cirrhosis, and abolishes local recurrence. We describe the outcomes of patients with HCC who underwent liver transplantation in two liver transplantation centers in Chile. METHODS: This study is a clinical series elaborated from the liver transplantation database of Pontificia Universidad Católica and Clínica Alemana between 1993 and 2009. The survival of patients was calculated using the Kaplan-Meier survival analysis. The significant alpha level was defined as <.05. RESULTS: From 250 liver transplantations performed in this period, 29 were due to HCC. At the end of the study, 25 patients (86%) were alive. The mean recurrence-free survival was 30 months (range 5 months to 8 years). The 5-year survival for patients transplanted for HCC was >80%; however, the 5-year overall survival of patients who exceeded the Milan criteria in the explants was 66%. There was no difference in overall survival between patients transplanted for HCC versus other diagnosis (P = .548). CONCLUSION: This series confirmed that liver transplantation is a good treatment for patients with HCC within the Milan criteria.
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| Authors | M Gabrielli, M Vivanco, J Hepp, J Martínez, R Pérez, J Guerra, M Arrese, E Figueroa, A Soza, R Yáñes, R Humeres, H Rios, J M Palacios, R Zapata, E Sanhueza, J Contreras, G Rencoret, R Rossi, N Jarufe |
| Journal | Transplantation proceedings (Transplant Proc) 2010 Jan-Feb Vol. 42 Issue 1 Pg. 299-301 ISSN: 1873-2623 [Electronic] United States |
| PMID | 20172336 (Publication Type: Journal Article) |
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