Urinary cytokines and renal Doppler study in Kawasaki disease.

Abstract

OBJECTIVE:

To investigate whether renal vasculitis is the sole cause or merely a contributing cause of renal inflammation in Kawasaki disease (KD).

STUDY DESIGN:

This prospective study in a university medical center in Taiwan enrolled 24 children with KD between June 2004 and November 2005. All patients underwent a technetium-99 m dimercaptosuccinic acid scintigraphy single-photon emission computed tomography scan, the results of which were used to group the patients with KD as with or without renal involvement. Urine samples underwent a cytokine analysis. Renal Doppler ultrasonography was used to evaluate renal vasculitis by measuring the pulsatility index (PI) and resistance index (RI).

RESULTS:

Ten of the 24 patients (42%) with renal inflammatory foci were the study group; the remainder composed the control group. Urinary interleukin (IL)-6 levels were significantly higher in the study group (496.7 +/- 310.9 vs 115.0 +/- 65.9 ng/g urinary creatinine; P < .01), as were PI values (1.85 +/- 0.70 vs 1.44 +/- 0.53; P < .05). Urinary IL-6 levels and PI values were significantly (P < .05) correlated.

CONCLUSIONS:

Increased urinary IL-6 and elevated renal Doppler measures suggest that immune-mediated vasculitis is one of the mechanisms causing renal inflammation in KD.

• Authors: Jing-Ming Wu, Yuan-Yow Chiou, Wen-Pin Hung, Nan-Tsing Chiu, Mei-Ju Chen, Jieh-Neng Wang
• Journal: The Journal of pediatrics (J Pediatr) Vol. 156 Issue 5 Pg. 792-7 (May 2010) ISSN: 1097-6833 [Electronic] United States
• PMID: 20171655 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-6
• Radiopharmaceuticals
• Technetium Tc 99m Dimercaptosuccinic Acid
• Creatinine

Topics

• Blood Flow Velocity
• Child, Preschool
• Creatinine (urine)
• Female
• Humans
• Infant
• Interleukin-6 (urine)
• Kidney (diagnostic imaging)
• Kidney Diseases (diagnostic imaging, urine)
• Male
• Mucocutaneous Lymph Node Syndrome (diagnostic imaging, urine)
• Pulsatile Flow
• Radiopharmaceuticals
• Renal Artery (diagnostic imaging)
• Technetium Tc 99m Dimercaptosuccinic Acid
• Tomography, Emission-Computed, Single-Photon
• Ultrasonography, Doppler, Pulsed
• Vascular Resistance
• Vasculitis (diagnostic imaging, urine)