[Therapy comparison between the combination hydergine/nifedipine and nifedipine alone in patients with isolated systolic hypertension].

The effect of Hydergine/Nifedipine (Pontuc) on blood pressure in supine or exercise blood pressure as well as subjective well-being was evaluated in a randomized, double-blind interindividual comparison with Nifedipine in 50 elderly out-patients (34 females, 16 males) with mostly pretreated isolated systolic hypertension. In addition to a nearly unchanged diastolic blood pressure during treatment the results prove that the drop in systolic blood pressure was statistically significant greater after treatment with Hydergine/Nifedipine and the normalization rate of the blood pressure was 81% in comparison to 69% after Nifedipine. Both drugs comparatively improved the subjective well-being of these geriatric patients. As drug specific adverse events flush symptoms were more frequent in the Nifedipine group, whereas in the Hydergine/Nifedipine group gastrointestinal symptoms occurred more often.
AuthorsP Dominiak, G Weidinger
JournalMedizinische Klinik (Munich, Germany : 1983) (Med Klin (Munich)) Vol. 86 Issue 1 Pg. 15-9 (Jan 15 1991) ISSN: 0723-5003 [Print] GERMANY
Vernacular TitleTherapievergleich zwischen der Kombination Hydergin/Nifedipin und Nifedipin bei Patienten mit isolierter systolischer Hypertonie.
PMID2017111 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Dihydroergotoxine
  • Nifedipine
  • Aged
  • Blood Pressure (drug effects)
  • Dihydroergotoxine (administration & dosage)
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Hypertension (drug therapy)
  • Male
  • Nifedipine (administration & dosage)

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