Abstract | BACKGROUND: METHODS: We randomly assigned 47 patients with newly diagnosed active proliferative lupus nephritis class III or IV to open-label oral MMF 2 g/day for 6 months or intravenous cyclophosphamide 0.5-1 g/m(2) monthly for 6 months in addition to corticosteroids. RESULTS: In the intention-to-treat analysis, 14 of the 24 patients (58.33%) receiving MMF and 12 of the 23 patients receiving cyclophosphamide (52.17%) had remission (P = 0.48); complete remission occurred in 6 of the 24 patients (25%) and 5 of the 23 patients (21.74%), respectively (P = 0.53). Improvements in packed cell volume, the erythrocyte sedimentation rate, anti- double-stranded DNA antibodies titer (anti-dsDNA), serum complement, proteinuria, urinary activity, renal function, serum soluble interleukin-2 receptor alpha concentration and the systemic lupus activity measure score were similar in both groups. Two patients assigned to MMF and another patient assigned to IVC developed end-stage renal failure with commencement of dialysis. Adverse events were similar. Major infections occurred in two patients in each group. There was no difference in gastrointestinal side effects, but more diarrhea occurred in those receiving MMF. CONCLUSION:
|
Authors | Eid M El-Shafey, Said H Abdou, Mohamed M Shareef |
Journal | Clinical and experimental nephrology
(Clin Exp Nephrol)
Vol. 14
Issue 3
Pg. 214-21
(Jun 2010)
ISSN: 1437-7799 [Electronic] Japan |
PMID | 20169461
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Cyclophosphamide
- Mycophenolic Acid
|
Topics |
- Adult
- Cyclophosphamide
(administration & dosage, adverse effects)
- Female
- Humans
- Infusions, Intravenous
- Lupus Nephritis
(drug therapy)
- Male
- Mycophenolic Acid
(analogs & derivatives, therapeutic use)
- Remission Induction
- Treatment Outcome
|