Abstract |
The purpose of this study was to observe early lesions of rat epiphyseal plates and metaphysis caused by T-2 toxin and T-2 toxin combined with a low nutrition diet to determine possible pathogenic factors of Kashin-Beck disease (KBD). Ninety Wistar rats were divided into three groups. Group A was fed with a normal diet as control; group B was fed with a normal diet and T-2 toxin; and group C was fed with a low nutrition diet and T-2 toxin. The left knee specimens were collected, fixed in formaldehyde solution, stained by hematoxylin and eosin and Masson. After two weeks, the epiphyseal plate showed necrosis of chondrocytes in groups B and C. After four weeks, more obvious chondrocyte necrosis appeared. The positive rate of Lamellar necrosis in group C was significantly higher than that in groups B and A (P < 0.01). Metaphyseal trabecular bone showed sparse disorder and disruption in group C. T-2 toxin combined with a low nutrition diet could lead to more serious chondrocyte necrosis in the epiphyseal plate and disturb metaphyseal trabecular bone formation.
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Authors | Yun-fen Yao, Peng-de Kang, Xing-bo Li, Jing Yang, Bing Shen, Zong-ke Zhou, Fu-xing Pei |
Journal | International orthopaedics
(Int Orthop)
Vol. 34
Issue 8
Pg. 1351-6
(Dec 2010)
ISSN: 1432-5195 [Electronic] Germany |
PMID | 20169345
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animal Nutritional Physiological Phenomena
- Animals
- Bone Development
(drug effects)
- Chondrocytes
(drug effects, pathology)
- Diet
(adverse effects)
- Epiphyses
(drug effects)
- Female
- Growth Plate
(drug effects)
- Hindlimb
- Male
- Necrosis
(chemically induced)
- Nutrition Disorders
- Rats
- Rats, Wistar
- T-2 Toxin
(toxicity)
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