Abstract | OBJECTIVE: METHODS AND RESULTS:
APOE*3 Leiden mice, maintained on a high- cholesterol diet, were treated for up to 18 weeks with AMP-DNM. The iminosugar prevented hyperlipidemia, generated a less atherogenic lipid profile, and induced a dramatic reduction in the development of atherosclerotic lesions. At the highest dose, no lesions were detectable. The effect of AMP-DNM was associated with a decrease in liver cholesterol, an increase in bile secretion, and enhanced excretion of cholesterol in the feces. Similar effects of AMP-DNM were observed in mice deficient for the low-density lipoprotein receptor. CONCLUSION:
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Authors | Florence Bietrix, Elisa Lombardo, Cindy P A A van Roomen, Roelof Ottenhoff, Mariska Vos, Patrick C N Rensen, Arthur J Verhoeven, Johannes M Aerts, Albert K Groen |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 30
Issue 5
Pg. 931-7
(May 2010)
ISSN: 1524-4636 [Electronic] United States |
PMID | 20167657
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoproteins E
- Enzyme Inhibitors
- Glycosphingolipids
- N-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin
- Receptors, LDL
- 1-Deoxynojirimycin
- Cholesterol
- Glucosyltransferases
- ceramide glucosyltransferase
- Adamantane
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Topics |
- 1-Deoxynojirimycin
(analogs & derivatives, pharmacology)
- Adamantane
(analogs & derivatives, pharmacology)
- Animals
- Apolipoproteins E
(genetics)
- Atherosclerosis
(genetics, metabolism, prevention & control)
- Bile
(metabolism)
- Cholesterol
(blood)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Down-Regulation
- Enzyme Inhibitors
(pharmacology)
- Feces
(chemistry)
- Female
- Glucosyltransferases
(antagonists & inhibitors, metabolism)
- Glycosphingolipids
(biosynthesis)
- Hyperlipidemias
(genetics, metabolism, prevention & control)
- Kinetics
- Liver
(drug effects, metabolism)
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Mutation
- Receptors, LDL
(deficiency, genetics)
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