Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro.

Abstract

A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis.

• Authors: Ching Tung Lum, Xiong Liu, Raymond Wai-Yin Sun, Xiang-Ping Li, Ying Peng, Ming-Liang He, Hsiang Fu Kung, Chi-Ming Che, Marie C M Lin
• Journal: Cancer letters (Cancer Lett) Vol. 294 Issue 2 Pg. 159-66 (Aug 28 2010) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 20163914 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Metalloporphyrins
• RNA, Messenger
• gold (III) porphyrin 1a
• Gold
• Monoacylglycerol Lipases

Topics

• Animals
• Apoptosis (drug effects)
• Cell Growth Processes (drug effects)
• Cell Line, Tumor
• Cell Movement (drug effects)
• Down-Regulation (drug effects)
• Gene Expression Profiling
• Gold (pharmacology)
• Humans
• Immunohistochemistry
• Liver Neoplasms, Experimental (prevention & control, secondary)
• Lung Neoplasms (prevention & control, secondary)
• Male
• Metalloporphyrins (pharmacology)
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Monoacylglycerol Lipases (biosynthesis, genetics)
• Nasopharyngeal Neoplasms (blood supply, drug therapy, enzymology, pathology)
• Neovascularization, Pathologic (drug therapy, pathology)
• RNA, Messenger (biosynthesis, genetics)
• Rats
• Xenograft Model Antitumor Assays