Nanofiber micro-dispersed oxidized cellulose as a carrier for topical antimicrobials: first experience.

Abstract

BACKGROUND:

Micro-dispersed oxidized cellulose, already used for hemostasis, might be helpful for introduction of an antimicrobial drug.

AIM:

To examine the effect of topically applied gentamicin attached to a new biodegradable carrier formed by micro-dispersed oxidized cellulose in microfiber and nanofiber form for treatment of acute wound infection and to assess the influence of this carrier on healing.

MATERIALS AND METHODS:

A model of a full-thickness infected dermal wound was created in 12 female domestic pigs. The effectiveness of topical gentamicin delivered with micro-dispersed oxidized cellulose carrier was tested in acute wound infections caused by Staphylococcus aureus, Pseudomonas aeruginosa, or Escherichia coli.

RESULTS:

The effectiveness of nanofiber micro-dispersed oxidized cellulose with gentamicin was proved according to culture findings. When assessed macroscopically, 100% of wounds treated by the nanofiber product had no signs of local infection. When microfiber micro-dispersed oxidized cellulose was used, cultures demonstrated residual bacteria in 94.4% of treated incisions despite the absence of clinically recognized infection.

CONCLUSIONS:

Micro-dispersed oxidized cellulose carrier with a sufficient concentration of an attached antibiotic appears to be effective for the treatment of full-thickness skin infections. The positive influence of the product on the healing of a dermal incision was shown, and a good hemostatic effect was confirmed.

• Authors: Petr Lochman, Michal Plodr, Jirí Páral, Karel Smejkal
• Journal: Surgical infections (Surg Infect (Larchmt)) Vol. 11 Issue 1 Pg. 29-32 (Feb 2010) ISSN: 1557-8674 [Electronic] United States
• PMID: 20163259 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents, Local
• Cellulose, Oxidized
• Drug Carriers
• Gentamicins

Topics

• Administration, Topical
• Animals
• Anti-Infective Agents, Local (therapeutic use)
• Bacterial Infections (drug therapy)
• Cellulose, Oxidized (administration & dosage)
• Disease Models, Animal
• Drug Carriers (administration & dosage)
• Escherichia coli (drug effects, isolation & purification)
• Female
• Gentamicins (therapeutic use)
• Nanofibers (administration & dosage)
• Pseudomonas aeruginosa (drug effects, isolation & purification)
• Staphylococcus aureus (drug effects, isolation & purification)
• Swine
• Treatment Outcome
• Wound Healing
• Wound Infection (drug therapy)