Abstract |
This study evaluated immunomodulatory properties and the sub-acute toxicity profile of two fractions of the aqueous alcoholic extract of the dried calyx of Hibiscus sabdariffa in experimental animals. Immunomodulatory activity was evaluated using red blood cell-induced immunostimulation. The fractions were not found to be toxic after 7-day administration, though there was severe weight loss with the residual water-soluble fraction (RWSF) and weight gain with the ethyl acetate soluble fraction (EAC). The EAC exhibited a significant dose-dependent immunostimulation (p<0.05) higher than that observed for levamisole (positive control). The residual water-soluble fraction exhibited immunostimulatory activity at 100 mg/kg body weight. The two fractions caused a significant reduction in production of tissue necrosis factor-alpha and an increase in interleukin 10 (IL-10).
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Authors | Titilayo Fakeye |
Journal | African journal of traditional, complementary, and alternative medicines : AJTCAM
(Afr J Tradit Complement Altern Med)
Vol. 5
Issue 4
Pg. 394-8
(Jun 18 2008)
ISSN: 2505-0044 [Electronic] Nigeria |
PMID | 20161963
(Publication Type: Journal Article)
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