Abstract | BACKGROUND: METHODS: RESULTS: We found that letrozole and ZA induce levels of apoptosis in breast cancer cells in vitro that are significantly greater compared with treatment with each drug alone. However, this potentially, synergistic relationship is drug-sequence dependent, occurring only when cells are treated with letrozole, followed by ZA. The converse sequence, or administering drugs simultaneously, induces levels of apoptosis no greater than each drug alone. CONCLUSION: Owing to the enhanced anti-tumour efficacy of sequential drug administration, our findings may indicate that, for post-menopausal women who require treatment with letrozole, ZA should also be considered.
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Authors | H L Neville-Webbe, R E Coleman, I Holen |
Journal | British journal of cancer
(Br J Cancer)
Vol. 102
Issue 6
Pg. 1010-7
(Mar 16 2010)
ISSN: 1532-1827 [Electronic] England |
PMID | 20160726
(Publication Type: Journal Article)
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Chemical References |
- Aromatase Inhibitors
- Bone Density Conservation Agents
- Diphosphonates
- Imidazoles
- Nitriles
- Triazoles
- Zoledronic Acid
- Letrozole
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Topics |
- Algorithms
- Antineoplastic Combined Chemotherapy Protocols
(pharmacology)
- Apoptosis
(drug effects)
- Aromatase Inhibitors
(administration & dosage, pharmacology)
- Bone Density Conservation Agents
(administration & dosage, pharmacology)
- Breast Neoplasms
(pathology)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Cell Survival
(drug effects)
- Diphosphonates
(administration & dosage, pharmacology)
- Dose-Response Relationship, Drug
- Drug Evaluation, Preclinical
- Drug Synergism
- Female
- Humans
- Imidazoles
(administration & dosage, pharmacology)
- Letrozole
- Nitriles
(administration & dosage, pharmacology)
- Triazoles
(administration & dosage, pharmacology)
- Zoledronic Acid
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