Abstract | OBJECTIVE: METHODS: In this retrospective analysis we have identified 39 patients with relapsed or refractory multiple myeloma by means of case research, who have been treated at our institution with bendamustine as salvage therapy. After in median 2 lines of prior therapy (range: 1-5) patients received in median 3 (range: 1-10) cycles of bendamustine. Bendamustine dosage was 80-150 mg on day 1+2 of a monthly cycle. Bendamustine was administered as monotherapy in 39% of patients, whereas 61% received concomitant steroids. RESULTS: Toxicity was mild to moderate. Response rates were as follows: 3% vgPR, 33% PR, 18% MR, 26% SD and 20% PD. The median event-free and overall survival were 7 and 17 months, respectively. CONCLUSIONS:
|
Authors | M Michael, I Bruns, E Bölke, F Zohren, A Czibere, N N Safaian, F Neumann, R Haas, G Kobbe, Roland Fenk |
Journal | European journal of medical research
(Eur J Med Res)
Vol. 15
Issue 1
Pg. 13-9
(Jan 29 2010)
ISSN: 0949-2321 [Print] England |
PMID | 20159666
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antineoplastic Agents
- Nitrogen Mustard Compounds
- Bendamustine Hydrochloride
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents
(administration & dosage, adverse effects)
- Bendamustine Hydrochloride
- Disease-Free Survival
- Female
- Humans
- Male
- Middle Aged
- Multiple Myeloma
(drug therapy, mortality)
- Nitrogen Mustard Compounds
(administration & dosage, adverse effects)
- Recurrence
- Retrospective Studies
- Survival Analysis
- Treatment Outcome
|