Polybioside, a neuroactive compound from the venom of the social wasp Polybia paulista.

Abstract

Polybioside (1) was isolated from the venom of the social wasp Polybia paulista, and its structure was assigned as 3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 3-(1H-imidazol-4-yl)propanimidate by NMR and MS protocols. The application of polybioside in rat brain, followed by the detection of c-Fos protein expression in some brain regions, indicated the compound is neuroactive in a number of brain areas. Polybioside causes convulsions in rats, even when peripherally applied.

• Authors: Daniel M Saidemberg, Luiz C da Silva-Filho, Lilian M M Cesar Tognoli, Claudio F Tormena, Mario S Palma
• Journal: Journal of natural products (J Nat Prod) Vol. 73 Issue 4 Pg. 527-31 (Apr 23 2010) ISSN: 1520-6025 [Electronic] United States
• PMID: 20158240 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Central Nervous System Agents
• Glucosides
• Imidazoles
• Proto-Oncogene Proteins c-fos
• Wasp Venoms
• polybioside

Topics

• Animals
• Brain (cytology, drug effects)
• Brazil
• Central Nervous System Agents (chemistry, isolation & purification, pharmacology)
• Glucosides (chemistry, isolation & purification, pharmacology)
• Imidazoles (chemistry, isolation & purification, pharmacology)
• Male
• Molecular Structure
• Neurons (drug effects)
• Nuclear Magnetic Resonance, Biomolecular
• Proto-Oncogene Proteins c-fos (drug effects, metabolism)
• Rats
• Rats, Wistar
• Seizures (chemically induced)
• Wasp Venoms (chemistry)
• Wasps (chemistry)