Protective effect of decursinol on mouse models of sepsis: enhancement of interleukin-10.

Abstract

The effects of decursinol on various models of sepsis were investigated. Intra-peritoneal pretreatment of mice with various doses of decursinol (1~100 mg/kg) effectively suppressed lethality induced in three mouse models of experimental sepsis, i.e., lipopolysaccharide (LPS)/D-galactosamine (GalN), high-dose LPS (20 mg/kg), and cecal ligation and puncture (CLP). Intra-peritoneal pretreatment of mice with decursinol (50 mg/kg) markedly enhanced the LPS/GalN-induced increase of plasma interleukin-10 (IL-10) levels, without affecting plasma TNF-alpha, IL-6 and IL-12 levels. These results suggest that decursinol could be effective for prevention or treatment of sepsis.

• Authors: Jun-Sub Jung, Ji-Jing Yan, Dong-Keun Song
• Journal: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology (Korean J Physiol Pharmacol) Vol. 12 Issue 2 Pg. 79-81 (Apr 2008) ISSN: 2093-3827 [Electronic] Korea (South)
• PMID: 20157398 (Publication Type: Journal Article)