Abstract | INTRODUCTION:
Myrtol standardized is established in the treatment of acute and chronic bronchitis and sinusitis. It increases mucociliar clearance and has muco-secretolytic effects. Additional anti-inflammatory and antioxidative properties have been confirmed for Myrtol standardized, eucalyptus oil, and orange oil in several in vitro studies. OBJECTIVE: MATERIAL AND METHODS: RESULTS: In comparison with negative controls, pre-cultured Myrtol, eucalyptus oil and orange oil (10-4%) reduced in the LPS-activated alveolar macrophages ROS release significantly after 1+20 h as follows: Myrtol -17.7% (P=0.05), eucalyptus oil -21.8% (P<0.01) and orange oil -23.6% (P<0.01). Anti-oxidative efficacy was comparable to NAC (1 mmol/l). Essential oils also induced a TNF-alpha reduction: Myrtol (-37.3%, P<0.001), eucalyptus oil (-26.8%, P<0.01) and orange oil (-26.6%, P<0.01). TNF-a reduction at 1+4 h and 1+20 h did not vary ( Myrtol: -31.9% and -37.3% respectively, P= 0.372) indicating that this effect occurs early and cannot be further stimulated. Myrtol reduced the release of GM-CSF by -35.7% and that of IL-8 only inconsiderably. CONCLUSIONS: All essential oils tested have effective antioxidative properties in ex vivo cultured and LPS-stimulated alveolar macrophages. Additionally, Myrtol inhibited TNF-a and GM-CSF release best indicating additional potent anti-inflammatory activity.
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Authors | U Rantzsch, G Vacca, R Dück, A Gillissen |
Journal | European journal of medical research
(Eur J Med Res)
Vol. 14 Suppl 4
Pg. 205-9
(Dec 07 2009)
ISSN: 0949-2321 [Print] England |
PMID | 20156758
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Drug Combinations
- Interleukin-8
- Monoterpenes
- Oils, Volatile
- Reactive Oxygen Species
- Tumor Necrosis Factor-alpha
- myrtol
- Granulocyte-Macrophage Colony-Stimulating Factor
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Topics |
- Adult
- Aged
- Anti-Inflammatory Agents
(pharmacology)
- Drug Combinations
- Female
- Granulocyte-Macrophage Colony-Stimulating Factor
(antagonists & inhibitors)
- Humans
- Interleukin-8
(antagonists & inhibitors)
- Macrophages, Alveolar
(drug effects, immunology)
- Male
- Middle Aged
- Monoterpenes
(pharmacology)
- Oils, Volatile
(pharmacology)
- Pulmonary Disease, Chronic Obstructive
(drug therapy)
- Reactive Oxygen Species
(metabolism)
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
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