Abstract |
Epstein-Barr virus-associated smooth muscle tumors (EBV-SMT) are distinct lesions that occur in immunocompromised patients. EBV-SMT following solid organ transplantation are rare and generally have an indolent biological behavior. Post-transplant EBV-SMT have been reported in various anatomical locations. This report describes a synchronous and multicentric development of EBV-SMT in liver, mesentery, and lung of a 33-yr-old male patient, 10 yr after a deceased allograft renal transplantation. The hepatic and mesenteric tumors were available for study. These tumors were composed of bland looking, desmin-positive, spindle-shaped cells which showed a strong nuclear staining for EBV with in situ hybridization technique. A literature review of post solid organ transplant EBV-SMT in the liver and lung, particularly regarding their pathogenesis, synchronicity and biological behavior would be provided.
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Authors | T Al Hussain, A Haleem, K O Alsaad |
Journal | Clinical transplantation
(Clin Transplant)
2010 Sep-Oct
Vol. 24
Issue 5
Pg. 579-84
ISSN: 1399-0012 [Electronic] Denmark |
PMID | 20156224
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2010 John Wiley & Sons A/S. |
Chemical References |
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Topics |
- Adult
- Biomarkers, Tumor
(analysis)
- Epstein-Barr Virus Infections
(pathology, virology)
- Herpesvirus 4, Human
(isolation & purification)
- Humans
- Immunoenzyme Techniques
- Kidney Failure, Chronic
(surgery)
- Kidney Transplantation
- Laparotomy
- Liver Neoplasms
(chemistry, pathology, virology)
- Lung Neoplasms
(chemistry, pathology, virology)
- Male
- Mesentery
(pathology, virology)
- Neoplasms, Multiple Primary
(chemistry, pathology, virology)
- Peritoneal Neoplasms
(chemistry, pathology, virology)
- Smooth Muscle Tumor
(chemistry, pathology, virology)
- Tomography, X-Ray Computed
- Transplantation, Homologous
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