Synovial sarcoma of the chest wall.

Abstract

We here report a rare case of synovial sarcoma of the chest wall. A 71-year-old Japanese woman noticed a left anterior chest wall mass after twice having had surgery for lung cancer. An aspiration biopsy diagnosed synovial sarcoma. She then underwent a surgical resection. Pathology examination revealed a biphasic-type synovial sarcoma. When the prepared RNA from the tumor was subjected to a polymerase chain reaction, SYT-SSX1 fusion gene transcripts were demonstrated. Patients with the SYT-SSX1 fusion gene have a worse clinical outcome than patients with SYT-SSX2-positive tumors. After a second surgery, performed in 1 year later, there was no evidence of recurrence for 30 months; however, careful observation may be required.

• Authors: Daigo Kawano, Ichiro Yoshino, Fumihiro Shoji, Yosuke Morodomi, Tokujiro Yano, Yoshihiko Maehara
• Journal: General thoracic and cardiovascular surgery (Gen Thorac Cardiovasc Surg) Vol. 58 Issue 2 Pg. 95-7 (Feb 2010) ISSN: 1863-6713 [Electronic] Japan
• PMID: 20155347 (Publication Type: Case Reports, Journal Article)

Chemical References

• Oncogene Proteins, Fusion
• SYT-SSX fusion protein

Topics

• Aged
• Biopsy, Needle
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Immunohistochemistry
• Neoplasm Invasiveness
• Neoplasm Recurrence, Local
• Oncogene Proteins, Fusion (genetics)
• Predictive Value of Tests
• Radiotherapy, Adjuvant
• Reoperation
• Sarcoma, Synovial (genetics, pathology, radiotherapy, surgery)
• Thoracic Neoplasms (genetics, pathology, radiotherapy, surgery)
• Thoracic Surgical Procedures
• Thoracic Wall (pathology, surgery)
• Tomography, X-Ray Computed
• Treatment Outcome