[Transcatheter arterial chemoembolization with a lipophilic platinum complex SM-11355(miriplatin hydrate)--safety and efficacy in combination with embolizing agents].

Abstract

SM-11355 is a cisplatin derivative with high affinity for iodized ethyl esters of fatty acids of poppyseed oil. Clinical trials have shown that SM-11355 is effective for treatment of hepatocellular carcinoma. Transcatheter arterial chemoembolization is commonly used in combination with embolizing agents, but concomitant use of SM-11355 and embolizing agents has not been evaluated in previous trials. In this study, the safety and efficacy of SM-11355 in combination with embolizing agents were investigated in 10 patients with hepatocellular carcinoma. An anti-tumor effect of TE4 was achieved in 4 of 9 patients and no serious adverse events were observed, indicating that this therapy can be used safely for hepatocellular carcinoma.

• Authors: Kenji Ikeda, Takuji Okusaka, Masafumi Ikeda, Manabu Morimoto
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 37 Issue 2 Pg. 271-5 (Feb 2010) ISSN: 0385-0684 [Print] Japan
• PMID: 20154484 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Lipids
• Organoplatinum Compounds
• miriplatin

Topics

• Aged
• Carcinoma, Hepatocellular (blood, diagnosis, therapy)
• Catheterization, Peripheral
• Chemoembolization, Therapeutic
• Female
• Humans
• Lipids (chemistry)
• Liver Neoplasms (blood, diagnosis, therapy)
• Male
• Middle Aged
• Organoplatinum Compounds (adverse effects, chemistry, therapeutic use)