HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

One-year evaluation of combined treatment with an intranasal corticosteroid and montelukast for chronic rhinosinusitis associated with asthma.

AbstractOBJECTIVES:
Chronic rhinosinusitis associated with asthma is often difficult to treat effectively with intranasal corticosteroids alone. Thus, the aim of this study was to evaluate the effectiveness of combination treatment with an intranasal corticosteroid and a leukotriene-receptor antagonist (montelukast) in reducing the size of nasal polyps.
METHODS:
The subjects of this study were 20 patients with chronic rhinosinusitis associated with adult-onset asthma, which was being treated with inhaled corticosteroids. All patients were treated with intranasal fluticasone propionate, 200 microg/day, and montelukast, 10 mg/day, for 1 year. The size of nasal polyps and the score of sinus shadows were assessed with nasal endoscopy and computed tomography (CT), respectively, before and after treatment. The peripheral blood eosinophil counts were also evaluated before and after treatment.
RESULTS:
Nasal polyps were significantly smaller after both 6 months (p<0.01) and 12 months of treatment (p<0.01) than before treatment. The decrease in the shadow score was statistically significant after both 6 months (p<0.01) and 12 months of treatment (p<0.01). Significant reductions in peripheral blood eosinophil counts were also seen after both 6 months (p<0.05) and 12 months of treatment (p<0.01). A significant correlation was found between the rate of change in the peripheral blood eosinophil count and that in the CT score after both 6 months (r=0.578, p=0.012) and 12 months (r=0.625, p=0.007).
CONCLUSION:
Combined treatment with intranasal fluticasone propionate and montelukast, for at least 1 year, is effective for chronic rhinosinusitis associated with adult-onset asthma.
AuthorsManabu Nonaka, Atsuko Sakanushi, Kaoru Kusama, Nozomu Ogihara, Toshiaki Yagi
JournalJournal of Nippon Medical School = Nippon Ika Daigaku zasshi (J Nippon Med Sch) Vol. 77 Issue 1 Pg. 21-8 (Feb 2010) ISSN: 1345-4676 [Print] Japan
PMID20154454 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Acetates
  • Adrenal Cortex Hormones
  • Androstadienes
  • Anti-Allergic Agents
  • Cyclopropanes
  • Leukotriene Antagonists
  • Quinolines
  • Sulfides
  • Fluticasone
  • montelukast
Topics
  • Acetates (administration & dosage)
  • Administration, Intranasal
  • Adrenal Cortex Hormones (administration & dosage)
  • Adult
  • Aged
  • Androstadienes (administration & dosage)
  • Anti-Allergic Agents (administration & dosage)
  • Asthma (complications, drug therapy)
  • Chronic Disease
  • Cyclopropanes
  • Drug Therapy, Combination
  • Eosinophils (cytology)
  • Female
  • Fluticasone
  • Humans
  • Leukotriene Antagonists (administration & dosage)
  • Male
  • Middle Aged
  • Nasal Polyps (diagnostic imaging)
  • Quinolines (administration & dosage)
  • Rhinitis, Allergic, Perennial (complications, diagnostic imaging, drug therapy)
  • Sinusitis (complications, diagnostic imaging, drug therapy)
  • Sulfides
  • Tomography, X-Ray Computed
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: