Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii.

Abstract

A new bisindole alkaloid, bisleuconothine A (1) consisting of an eburnane-aspidosperma type skeleton, was isolated from the bark of Leuconotis griffithii. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and X-ray analysis. Bisleuconothine A (1) showed cell growth inhibitory activity against various human cancer cell lines.

• Authors: Yusuke Hirasawa, Tomokazu Shoji, Takashi Arai, Alfarius E Nugroho, Jun Deguchi, Takahiro Hosoya, Nahoko Uchiyama, Yukihiro Goda, Khalijah Awang, A Hamid A Hadi, Motoo Shiro, Hiroshi Morita
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 20 Issue 6 Pg. 2021-4 (Mar 15 2010) ISSN: 1464-3405 [Electronic] England
• PMID: 20153644 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Indole Alkaloids
• bisleuconothine A

Topics

• Apocynaceae (chemistry)
• Cell Line, Tumor
• Drug Screening Assays, Antitumor
• Humans
• Indole Alkaloids (chemistry, isolation & purification, pharmacology)
• Magnetic Resonance Spectroscopy
• Models, Molecular