Synthesis, characterization and cytotoxicity of iodo-bridged binuclear platinum(II) complexes.

Abstract

Seven new iodo-bridged binuclear platinum(II) complexes [Pt(L)I2]2 (1-7) (L=n-butylamine, isopropylamine, m-toluidine, p-toluidine, diethylamine, N-methylaniline and aniline) have been synthesized and characterized by elemental analysis, conductivity, thermal analysis, IR, 1H NMR and mass spectra techniques. The cytotoxicity was tested by MTT assay. The results indicate that they have selectivity against tested carcinoma cell lines. For example, the complexes (3 and 7) have better cytotoxicity than cisplatin against Bel-7402 cell line, the complexes (2-5 and 7) have better cytotoxicity than cisplatin against Hela cell line. The results suggest that the species of amine has important effect on cytotoxicity, when L=m-toluidine, p-toluidine and aniline, the complexes have better cytotoxicity against tested carcinoma cell lines.

• Authors: Jinchao Zhang, Luwei Li, Xiaoyu Ji, Jing Sun, Liwei Wang, Ying Zhang
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 45 Issue 6 Pg. 2634-7 (Jun 2010) ISSN: 1768-3254 [Electronic] France
• PMID: 20153562 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antineoplastic Agents
• Organoplatinum Compounds
• Iodine

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cell Line, Tumor
• Drug Stability
• Humans
• Inhibitory Concentration 50
• Iodine (chemistry)
• Organoplatinum Compounds (chemical synthesis, chemistry, pharmacology)
• Spectrum Analysis
• Temperature