[Response to metronomic chemotherapy in a metastatic adenoid cystic carcinoma of the parotid gland].

Abstract

Formerly, salivary gland cancer was considered to be chemoresistant. Chemotherapy is indicated when distant metastases or inoperable locorregional disease are observed, although the chemotherapy schedule is not well defined. Data on chemotherapy treatment for adenoid cystic carcinoma consist of phase II trials. Most of these studies analyze therapies with a combination of agents at full dose, although there is no clear evidence that such treatment improves survival. The administration of cytotoxic agents with low doses at frequent, regular intervals with no drug-free interruptions is known as metronomic chemotherapy. Most head-to-head studies show similar or even superior therapeutic results with metronomic scheduling than with a maximum tolerated dose regime. Our case report shows for first time the clinical activity of low-dose paclitaxel and cisplatin chemotherapy given separately as a single agent in metastatic adenoid cystic carcinoma of the parotid.

• Authors: Laura Visa, Miguel Caballero, Juan J Grau
• Journal: Acta otorrinolaringologica espanola (Acta Otorrinolaringol Esp) 2010 Nov-Dec Vol. 61 Issue 6 Pg. 452-4 ISSN: 1988-3013 [Electronic] Spain
• Vernacular Title: Respuesta a quimioterapia metronómica en un carcinoma adenoide quístico metastásico de parótida.
• PMID: 20152955 (Publication Type: Case Reports, English Abstract, Journal Article)
• Copyright: Copyright © 2009 Elsevier España, S.L. All rights reserved.

Chemical References

• Antineoplastic Agents
• Paclitaxel
• Cisplatin

Topics

• Antineoplastic Agents (administration & dosage)
• Carcinoma, Adenoid Cystic (drug therapy, secondary)
• Cisplatin (administration & dosage)
• Drug Administration Schedule
• Female
• Humans
• Middle Aged
• Paclitaxel (administration & dosage)
• Parotid Neoplasms (drug therapy, pathology)