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A randomized, double-blind, placebo-controlled study of the efficacy and safety of bupropion for treating hypoactive sexual desire disorder in ovulating women.

AbstractOBJECTIVE:
To compare the efficacy of sustained-release (SR) bupropion to placebo in treating hypoactive sexual desire disorder (HSDD) in ovulating women.
PATIENTS AND METHODS:
After a 1-week, placebo lead-in phase, 232 treatment-seeking women with regular menstrual cycles were randomly assigned to bupropion SR 150 mg/daily (116) or placebo (116) for 12 weeks under double-blind conditions. Efficacy was assessed with the Brief Index of Sexual Functioning for Women (BISF-W), the Personal Distress Scale (PDS), the global efficacy question (GEQ; 'Did the treatment you received during the 12-week improve meaningful your sexual desire?') and overall patient satisfaction question ('Are you satisfied with the efficacy of your treatment?').
RESULTS:
The mean (sd) composite score on the BISF-W, increased from 15.8 (2.6) and 15.5 (2.2) at baseline to 33.9 (4.2) and 16.9 (2.6) in the bupropion and placebo groups, respectively (P= 0.001). The odds ratio (95% confidence interval) for response in the bupropion group relative to placebo was 3.2 (2.1-6.3). The thoughts/desire score more than doubled in patients treated with bupropion (P= 0.001). At the 12-week evaluation the reduction in the PDS scale was 29.4% in bupropion and 4.7% in the placebo group (P= 0.01). In response to the GEQ, of patients in the bupropion and placebo groups, 65.3%, and 4.3%, respectively, responded 'Definitely yes' (P= 0.001). Of patients in the bupropion and placebo groups, 71.8%, and 3.7%, respectively, were definitely satisfied with the efficacy of their treatment, (P= 0.001). After 12 weeks of treatment, 82 women (78.1%) in the bupropion and five (4.9%) in the placebo group were willing to continue therapy (P= 0.001).
CONCLUSIONS:
The results from this study indicate that bupropion SR is an effective and well-tolerated treatment for HSDD in ovulating women. Further controlled trials are warranted.
AuthorsMohammad Reza Safarinejad, Seyyed Yousof Hosseini, Majid Ali Asgari, Farid Dadkhah, Arsia Taghva
JournalBJU international (BJU Int) Vol. 106 Issue 6 Pg. 832-9 (Sep 2010) ISSN: 1464-410X [Electronic] England
PMID20151970 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Dopamine Uptake Inhibitors
  • Bupropion
Topics
  • Adult
  • Bupropion (adverse effects, therapeutic use)
  • Dopamine Uptake Inhibitors (adverse effects, therapeutic use)
  • Epidemiologic Methods
  • Female
  • Humans
  • Libido (drug effects)
  • Menstrual Cycle
  • Ovulation
  • Patient Satisfaction
  • Sexual Dysfunctions, Psychological (drug therapy)
  • Treatment Outcome
  • Young Adult

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