Abstract | BACKGROUND:
Pain relief is an important treatment goal for breast cancer patients with metastatic bone disease and treatment should be associated with a low rate of side effects. This interim analysis of a prospective non-interventional study documents the efficacy and safety of the amino- bisphosphonate ibandronate in the treatment of metastatic bone disease under real-life conditions. PATIENTS AND METHODS: RESULTS: At baseline, patients with ibandronate pretreatment tended to have lower mean pain scores and lower serum creatinine levels than those pre-treated with other bisphosphonates. Over the observation period, analgesic use did not increase. Among the 712 patients reporting pain at baseline, 70% achieved an improvement in pain severity during treatment with ibandronate, and there was no evidence to suggest relevant differences in mean pain reductions with IV or oral administration of ibandronate or according to prior bisphosphonate treatment. Skeletal-related events were rare (7%). Changes in serum creatinine levels during ibandronate treatment were small and both formulations of ibandronate were rated as well tolerated by physicians and patients. CONCLUSIONS: Data from this non-interventional study confirm the analgesic efficacy and safety profile of IV and oral ibandronate under real-life conditions.
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Authors | Ingo J Diel, Andreas H A Kurth, Hans-Bernd Sittig, Harald Meden, Michael Maasberg, Andreas Sandermann, Raoul Bergner |
Journal | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
(Support Care Cancer)
Vol. 18
Issue 10
Pg. 1305-12
(Oct 2010)
ISSN: 1433-7339 [Electronic] Germany |
PMID | 20151162
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bone Density Conservation Agents
- Diphosphonates
- Creatinine
- Ibandronic Acid
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Topics |
- Administration, Oral
- Aged
- Bone Density Conservation Agents
(administration & dosage, adverse effects, therapeutic use)
- Bone Neoplasms
(complications, drug therapy, secondary)
- Breast Neoplasms
(pathology)
- Creatinine
(blood)
- Diphosphonates
(administration & dosage, adverse effects, therapeutic use)
- Female
- Humans
- Ibandronic Acid
- Infusions, Intravenous
- Middle Aged
- Pain
(drug therapy, etiology)
- Prospective Studies
- Severity of Illness Index
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