Abstract |
The aim of this study was to evaluate the effects of metformin in addition to diet and exercise on endocrine and metabolic disturbances in women with polycystic ovary syndrome (PCOS) in a prospective, double-blind, randomized, placebo (PBO) control trial. Thirty women with insulin resistance and PCOS received lifestyle modification and 1500 mg of metformin or placebo for 4 months. Before and after treatment, body mass index, waist/hip ratio, blood pressure, hirsutism, and menstrual patterns were evaluated. Serum concentrations of gonadotropins, androgens, progesterone, glucose, insulin, and lipids were measured. Lifestyle interventions resulted in similar weight and menstrual cycle's improvements in both groups. A significant reduction in serum fasting insulin, HOMA index, waist and testosterone levels was only observed with metformin. There were no significant changes in androstenedione, dehydroepiandrosterone sulfate, gonadotropins, and lipids levels. No other changes were observed in hirsutism or blood pressure. These findings suggest that metformin has an additive effect to diet and exercise to improve parameters of hyperandrogenism and insulin resistance. Although, a small decrease in body weight trough lifestyle changes could be enough to improve menstrual cycles in insulin-resistant women with PCOS.
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Authors | Carolina Fux Otta, Myriam Wior, Gabriel S Iraci, Raquel Kaplan, Diana Torres, María Isabel Gaido, Eduardo P Wyse |
Journal | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
(Gynecol Endocrinol)
Vol. 26
Issue 3
Pg. 173-8
(Mar 2010)
ISSN: 1473-0766 [Electronic] England |
PMID | 20148739
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Chemical References |
- Hypoglycemic Agents
- Triglycerides
- Testosterone
- Luteinizing Hormone
- Follicle Stimulating Hormone
- Metformin
- Cholesterol
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Topics |
- Adult
- Blood Pressure
(physiology)
- Body Mass Index
- Cholesterol
(blood)
- Double-Blind Method
- Female
- Follicle Stimulating Hormone
(blood)
- Hirsutism
(physiopathology)
- Humans
- Hypoglycemic Agents
(administration & dosage)
- Insulin Resistance
(physiology)
- Life Style
- Luteinizing Hormone
(blood)
- Menstrual Cycle
(physiology)
- Metformin
(administration & dosage)
- Polycystic Ovary Syndrome
(blood, drug therapy, physiopathology, therapy)
- Statistics, Nonparametric
- Testosterone
(blood)
- Triglycerides
(blood)
- Waist-Hip Ratio
- Young Adult
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