Abstract |
Ankle sprains are common acute soft-tissue injuries. This 7-day open-label, multicentre, randomized study compared the efficacy and safety of celecoxib with non-selective non-steroidal anti-inflammatory drugs ( NSAIDs) in treating acute ankle sprain with moderate-to-severe ankle pain in 278 patients. Patients received either celecoxib (400 mg loading dose followed by 200 mg twice daily) or standard doses of non-selective NSAIDs. The primary endpoint was a change in the patient's assessment of ankle pain on a 0 mm (no pain) - 100 mm (worst possible pain) visual analogue scale (VAS) at day 3 compared with baseline. From a baseline of 73 mm, mean VAS pain scores decreased to 29 and 32 mm in the celecoxib and non-selective NSAID groups, respectively. The lower limit of the 95% confidence interval for the treatment difference with regard to change from baseline was greater than the pre-established non-inferiority margin of -10 mm. Using an initial loading dose, celecoxib was at least as efficacious as non-selective NSAIDs in treating acute pain due to ankle sprain.
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Authors | E Cardenas-Estrada, L G Oliveira, H L Abad, F Elayan, N Khalifa, T El-Usseini |
Journal | The Journal of international medical research
(J Int Med Res)
2009 Nov-Dec
Vol. 37
Issue 6
Pg. 1937-51
ISSN: 0300-0605 [Print] England |
PMID | 20146894
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Cyclooxygenase 2 Inhibitors
- Pyrazoles
- Sulfonamides
- Celecoxib
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Topics |
- Acute Disease
- Ankle Injuries
(complications)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, adverse effects, therapeutic use)
- Celecoxib
- Cyclooxygenase 2 Inhibitors
(administration & dosage, adverse effects, therapeutic use)
- Demography
- Dose-Response Relationship, Drug
- Endpoint Determination
- Humans
- Latin America
- Middle East
- Outcome Assessment, Health Care
- Pain
(drug therapy, etiology)
- Pyrazoles
(administration & dosage, adverse effects, therapeutic use)
- Sprains and Strains
(complications)
- Sulfonamides
(administration & dosage, adverse effects, therapeutic use)
- Treatment Outcome
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