Inhibition of cortiocosteroidogenesis by delta-9-tetrahydrocannabinol.

Abstract

ACTH, cholera toxin, cyclic AMP but not pregnenolone-induced steroidogenesis in Y-1 functional mouse adrenal tumor cells was significantly inhibited by delta-9-tetrahydrocannabinol, cannabidiol, and cannabinol. The inhibition of steroidogenesis could not be correlated with a general depression in cell function or viability. The data suggest that cannabinoids inhibit corticosteroidogenesis at a site between the synthesis of cAMP and of pregnenolone.

• Authors: W Warner, L S Harris, R A Carchman
• Journal: Endocrinology (Endocrinology) Vol. 101 Issue 6 Pg. 1815-20 (Dec 1977) ISSN: 0013-7227 [Print] United States
• PMID: 201449 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• 20-alpha-Dihydroprogesterone
• Progesterone
• Pregnenolone
• Dronabinol
• Adrenocorticotropic Hormone
• Cholera Toxin
• Cycloheximide
• Cyclic AMP

Topics

• 20-alpha-Dihydroprogesterone (biosynthesis)
• Adrenocorticotropic Hormone (pharmacology)
• Cell Division (drug effects)
• Cell Line
• Cholera Toxin (pharmacology)
• Cyclic AMP (pharmacology)
• Cycloheximide (pharmacology)
• Dronabinol (pharmacology)
• Oxygen Consumption (drug effects)
• Pregnenolone (pharmacology)
• Progesterone (analogs & derivatives)