Captopril and S-nitrosocaptopril as potent radiosensitizers: Comparative study and underlying mechanisms.

Abstract

In an effort to improve the issue of radiotherapy treatments, we tested whether S-nitrosocaptopril, a molecule combining a NO donor and an angiotensin converting enzyme inhibitor (ACE inhibitor), could temporarily improve the hemodynamic status of experimental tumors. We monitored the effect of S-nitrosocaptopril in TLT tumors using non rinvasive magnetic resonance techniques. We identified a time window during which tumor oxygenation was improved, as a result of a combined effect on tumor blood flow and oxygen consumption. Consequently, the administration of S-nitrosocaptopril contributed to the increase in efficacy of radiation therapy, an effect that was not observed with captopril alone.

• Authors: Bénédicte F Jordan, Julie Peeterbroeck, Oussama Karroum, Caroline Diepart, Julie Magat, Vincent Grégoire, Bernard Gallez
• Journal: Cancer letters (Cancer Lett) Vol. 293 Issue 2 Pg. 213-9 (Jul 28 2010) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 20144849 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Vasodilator Agents
• S-nitrosocaptopril
• Nitric Oxide
• Captopril

Topics

• Angiotensin-Converting Enzyme Inhibitors (pharmacology)
• Animals
• Captopril (analogs & derivatives, pharmacology)
• Hemodynamics (drug effects)
• Liver Neoplasms, Experimental (blood supply, metabolism, radiotherapy)
• Male
• Mice
• Neoplasm Transplantation
• Nitric Oxide
• Oxygen Consumption
• Radiation Tolerance (drug effects)
• Vasodilator Agents (pharmacology)