[Case of the month. Acute generalized exanthematous pustulosis due to an iodinated contrast radiodiagnostic agent].

Abstract

Iodinated contrast agents are frequently involved in delayed polymorphic adverse skin reactions. Acute generalized exanthematous pustulosis following administration of iodinated contrast agents is a rare but severe form of such reactions. The disease is characterized by the sudden occurrence of an erosive and pustular erythroderma with fever, leukocytosis and sometimes peripheral adenopathies and liver involvement. This condition is considered as an immunologic reaction, primarily involving T lymphocytes. The overall mortality reaches about 1%. Elucidating the differential diagnosis with other acute paroxysmal drug eruptions (toxic epidermal necrolysis, Steven-Johnson syndrome and drug hypersensitivity syndrome) is of paramount importance for establishing the adequate treatment of PEAG.

• Authors: P Paquet, G Vandenbossche, A F Nikkels, F Henry, G E Piérard
• Journal: Revue medicale de Liege (Rev Med Liege) Vol. 64 Issue 12 Pg. 601-5 (Dec 2009) ISSN: 0370-629X [Print] Belgium
• Vernacular Title: Le cas clinique de mois. Pustulose exanthématique aiguë généralisée due a un agent de contraste iodé pour radiodiagnostic.
• PMID: 20143742 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Contrast Media
• iobitridol
• Iohexol

Topics

• Aged, 80 and over
• Contrast Media (adverse effects)
• Female
• Humans
• Iohexol (adverse effects, analogs & derivatives)
• Skin Diseases, Vesiculobullous (chemically induced)