[Antidiabetogenic action of Pro-Gly-Arg and Pro-Gly-Pro-Arg peptides after their intranasal chronic administration to animals].

Abstract

It was shown that chronic (over 7 days) intranasal injection of the Pro-Gly-Arg tripeptide to rats in the dose 1 mg/kg before the injection of a diabetogenic dose of alloxan, promotes effective defense against development of insulin dependent diabetes mellitus. At the same time, the tetra-peptide Pro-Gly-Pro-Arg did not show a hypoglycemic affect during diabetes mellitus provocation. Administration of Pro-Gly-Arg and Pro-Gly-Pro-Arg peptides also activates anticoagulation potential.

• Authors: A M Ul'ianov, L A Liapina, T Iu Obergan, T A Shubina, V E Pastorova, L A Andreeva, N F Miasoedov, I P Ashmarin
• Journal: Izvestiia Akademii nauk. Seriia biologicheskaia (Izv Akad Nauk Ser Biol) 2009 Nov-Dec Issue 6 Pg. 740-4 ISSN: 1026-3470 [Print] Russia (Federation)
• PMID: 20143634 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hypoglycemic Agents
• Oligopeptides

Topics

• Administration, Intranasal
• Animals
• Blood Coagulation (drug effects)
• Diabetes Mellitus, Experimental (prevention & control)
• Hypoglycemic Agents (pharmacology)
• Male
• Oligopeptides (pharmacology)
• Rats
• Time Factors