[The influence of multipotent mesenchymal stromal cells of bone marrow on process of local radiation injury in rats after local beta-irradiation].

Abstract

The influence of multipotent mesenchymal stromal cells (MMSC), got from allogenic bone marrow, on local radiation injury in rats after beta-irradiation by a source 90Sr/90Y in a dose 140 Gy under various conditions and ways transplantation was studied. It was established, that transplantation MMSC, allocated on biodegradative membranes, which have been carried out for 21 day after an irradiation in conditions minor surgical of ulcers, resulted in reduction of the area of local beam defeats and acceleration of healing of skin, in comparison with the control of an irradiation. The introduction of suspension MMSC subcutaneous around of the center of a defeat at 8 day after an irradiation caused earlier healing of ulcers. It was concluded, that application of MMSC is perspective for treatment of local radiation injury and necessity of development of optimum conditions of their use at cell therapy of radiation injury of skin.

• Authors: B B Moroz, N A Onizhshenko, V G Lebedev, Iu B Deshevoĭ, G I Sidorovich, A V Lyrshchikova, M F Rasulov, M E Krasheninnikov, V I Sevast'ianov
• Journal: Radiatsionnaia biologiia, radioecologiia (Radiats Biol Radioecol) 2009 Nov-Dec Vol. 49 Issue 6 Pg. 688-93 ISSN: 0869-8031 [Print] Russia (Federation)
• PMID: 20143581 (Publication Type: Journal Article)

Topics

• Animals
• Back Injuries (etiology, surgery)
• Beta Particles
• Cells, Immobilized (transplantation)
• Male
• Mesenchymal Stem Cell Transplantation (methods)
• Mesenchymal Stem Cells (physiology)
• Multipotent Stem Cells (physiology, transplantation)
• Radiation Injuries, Experimental (surgery)
• Rats
• Rats, Wistar
• Skin Ulcer (etiology, surgery)
• Wound Healing