Lack of association between MnSOD Val16Ala polymorphism and breast cancer risk: a meta-analysis involving 58,448 subjects.

Abstract

Published data on the association between MnSOD Val16Ala polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Medline, PubMed, Embase, and Web of Science were searched. Crude ORs with 95% CIs were used to assess the strength of association between the MnSOD Val16Ala polymorphism and breast cancer risk. The pooled ORs were performed for co-dominant model (Val/Ala vs. Val/Val, Ala/Ala vs. Val/Val), dominant model (Ala/Ala + Val/Ala vs. Val/Val), and recessive model (Ala/Ala vs. Val/Ala + Val/Val), respectively. A total of 32 studies including 26,022 cases and 32,426 controls were involved in this meta-analysis. Overall, no significant associations were found between MnSOD Val16Ala polymorphism and breast cancer risk when all studies pooled into the meta-analysis (Val/Ala vs. Val/Val: OR = 1.022, 95% CI = 0.981-1.064; Ala/Ala vs. Val/Val: OR = 1.006, 95% CI = 0.934-1.083; dominant model: OR = 1.013, 95% CI = 0.962-1.066; and recessive model: OR = 0.985, 95% CI = 0.931-1.042). In the subgroup analysis by ethnicity or study design, still no significant associations were found for all comparison models. In conclusion, this meta-analysis suggests that the MnSOD Val16Ala polymorphism may be not associated with breast cancer development. However, large sample and representative population-based studies with homogeneous breast cancer patients and well-matched controls are warranted to confirm this finding.

• Authors: Li-Xin Qiu, Lei Yao, Chen Mao, Bo Chen, Ping Zhan, Hui Yuan, Kai Xue, Jian Zhang, Xi-Chun Hu
• Journal: Breast cancer research and treatment (Breast Cancer Res Treat) Vol. 123 Issue 2 Pg. 543-7 (Sep 2010) ISSN: 1573-7217 [Electronic] Netherlands
• PMID: 20143154 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Superoxide Dismutase
• superoxide dismutase 2

Topics

• Breast Neoplasms (enzymology, genetics)
• Case-Control Studies
• Female
• Genetic Predisposition to Disease
• Humans
• Linear Models
• Odds Ratio
• Phenotype
• Polymorphism, Genetic
• Risk Assessment
• Risk Factors
• Superoxide Dismutase (genetics)