Abstract | PURPOSE: METHODS: RESULTS: Both the PAO and HEL levels in the vitreous and serum were significantly higher in PDR patients than in those with MH (both p<0.01). The VEGF concentrations in the vitreous were higher in PDR patients than in those with MH (p<0.01); however, the VEGF concentrations in the serum were not different between the two groups (p=0.95). Positive correlations were found between the PAO and VEGF concentrations and between the HEL and VEGF concentrations in the vitreous of both the PDR and the MH patients. CONCLUSIONS: Our study revealed that the PAO, HEL, and VEGF concentrations in the vitreous were increased in PDR versus MH patients and that there were positive correlations among these factors. This is consistent with VEGF and lipid peroxide levels in the vitreous playing some role in the pathogenesis of PDR.
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Authors | Hiroshi Izuta, Nozomu Matsunaga, Masamitsu Shimazawa, Tetsuya Sugiyama, Tsunehiko Ikeda, Hideaki Hara |
Journal | Molecular vision
(Mol Vis)
Vol. 16
Pg. 130-6
(Jan 29 2010)
ISSN: 1090-0535 [Electronic] United States |
PMID | 20142849
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- N(epsilon)-hexanoyllysine
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Lysine
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Topics |
- Antioxidants
(metabolism)
- Diabetic Retinopathy
(blood, metabolism)
- Female
- Humans
- Lysine
(blood)
- Male
- Middle Aged
- Oxidative Stress
- Retinal Perforations
(blood, metabolism)
- Vascular Endothelial Growth Factor A
(blood, metabolism)
- Vitreous Body
(metabolism, pathology)
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