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Relationship between gene expressions of aquaporin 3 and 4 and various degrees of spleen-stomach dampness-heat syndrome in chronic superficial gastritis.

AbstractOBJECTIVE:
To explore the relationship between gene expressions of aquaporin (AQP) 3 and 4 and various degrees of spleen-stomach dampness-heat syndrome in chronic superficial gastritis (CSG).
METHODS:
Twenty-four CSG patients were divided into three groups according to the degrees of spleen-stomach dampness-heat syndrome: mild, moderate and severe groups. There were 8 patients in each group, and another 8 healthy persons were selected as normal control. Samples of mucosa of upper stomach in the included patients and normal persons were collected by gastroscopy, and then were stored in liquid nitrogen. The gene expressions of AQP3 and AQP4 in gastric tissue were examined by fluorescence quantitative polymerase chain reaction.
RESULTS:
The gene expressions of AQP3 and AQP4 in the moderate and severe groups were higher than that in the mild group and normal group (P<0.05, P<0.01). The gene expression of AQP3 in the severe group was higher than that in the moderate group (P<0.05).
CONCLUSION:
The gene expressions of AQP3 and AQP4 in gastric mucosa are different in patients with various degrees of spleen-stomach dampness-heat syndrome of CSG. There is a relationship between expressions of AQP3 and AQP4 genes and the degrees of spleen-stomach dampness-heat syndrome, and the gene expressions will increase with the aggravation of the dampness-heat syndrome.
AuthorsWu-xuan Mei, Shao-xian Lao, Na Yu, Zheng Zhou, Lie-ping Huang, Bin Hu
JournalZhong xi yi jie he xue bao = Journal of Chinese integrative medicine (Zhong Xi Yi Jie He Xue Bao) Vol. 8 Issue 2 Pg. 111-5 (Feb 2010) ISSN: 1672-1977 [Print] China
PMID20141731 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • AQP3 protein, human
  • AQP4 protein, human
  • Aquaporin 4
  • Aquaporin 3
Topics
  • Adult
  • Aquaporin 3 (genetics, metabolism)
  • Aquaporin 4 (genetics, metabolism)
  • Case-Control Studies
  • Female
  • Gastric Mucosa (metabolism)
  • Gastritis (diagnosis, metabolism)
  • Gene Expression
  • Humans
  • Male
  • Medicine, Chinese Traditional
  • Middle Aged

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