Abstract |
The effects of weekly doses of transfer factor in four patients with ataxia--telangiectasia were investigated following a total course of 2 months therapy. Transfer factor administration showed no influence on the absolute lymphocyte counts, T-cell rosettes or antibody titres to EBV, but it caused conversion of skin-test reactivity and production of MIF to various antigens. There was a dissociation in blastic transformation response, the skin-test responses and MIF production. Serum interferon levels were low before, and 2, 6 and 24 hr after, therapy. Clinically no improvement in infections was observed following transfer factor therapy.
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Authors | A I Berkel, F Ersoy, L B Epstein, L E Spitler |
Journal | Clinical and experimental immunology
(Clin Exp Immunol)
Vol. 29
Issue 3
Pg. 376-84
(Sep 1977)
ISSN: 0009-9104 [Print] England |
PMID | 201409
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antibodies, Viral
- Macrophage Migration-Inhibitory Factors
- Transfer Factor
- Interferons
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Topics |
- Antibodies, Viral
(analysis)
- Ataxia Telangiectasia
(therapy)
- Child
- Herpesvirus 4, Human
(immunology)
- Humans
- Interferons
(analysis)
- Leukocyte Count
- Lymphocyte Activation
- Macrophage Migration-Inhibitory Factors
(biosynthesis)
- Male
- Skin Tests
- Transfer Factor
(therapeutic use)
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