Abstract | OBJECTIVE: METHODS: RESULTS: Compared with the scrambled siRNA (DAI 3.42 +/- 0.67, histological score 4.65 +/- 1.53) and DSS group (3.73 +/- 0.55, 4.47 +/- 1.52), a significant decrease was observed in DAI (2.31 +/- 0.26) and histological score (2.19 +/- 0.77) in mice with NF-kappaB p65 siRNA (both P < 0.05). The expression of NF-kappaB p65 and TNF-alpha [(266 +/- 35) pg/ml] in mice with DSS-induced colitis was significantly reduced after treatment with NF-kappaB p65 siRNA (P < 0.05) in comparisons with the scrambled siRNA [(412 +/- 51) pg/ml] and DSS group pg/ml [(449 +/- 44) pg/ml]. CONCLUSION:
|
Authors | Li-na Cheng, Xiao-li Huang, Hua-tian Gan |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 89
Issue 34
Pg. 2416-9
(Sep 15 2009)
ISSN: 0376-2491 [Print] China |
PMID | 20137697
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- NF-kappa B
- RNA, Small Interfering
- Tumor Necrosis Factor-alpha
- Dextran Sulfate
|
Topics |
- Animals
- Colitis, Ulcerative
(metabolism)
- Dextran Sulfate
- Disease Models, Animal
- Female
- Intestinal Mucosa
(metabolism)
- Mice
- Mice, Inbred BALB C
- NF-kappa B
(genetics, metabolism)
- RNA, Small Interfering
- Tumor Necrosis Factor-alpha
(metabolism)
|