Indoleamine 2,3-dioxygenase in tumor induced tolerance.

Abstract

OBJECTIVE:

To review the recent studies about the role of indoleamine 2,3-dioxygenase (IDO) in tumor induced tolerance.

DATA SOURCES:

Published articles (1978 - 2009) on IDO and tumor induced tolerance were selected from Medline.

STUDY SELECTION:

Articles selected were relevant to development of IDO in tumor induced tolerance. Of all originally identified articles, 50 specially addressed the stated purpose.

RESULTS:

Recent work has revealed IDO at high levels in tumors and in tumor-draining lymph nodes and a close relationship between IDO activity and the regulatory T cells.

CONCLUSION:

Up-regulation of IDO is proven to be a mechanism of acquired tolerance in tumors, in which the closely coupled positive feedback system between IDO and regulatory T cells may be considered to play an important role.

• Authors: Xiao-Qian Liu, Xin Wang
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 122 Issue 24 Pg. 3072-7 (Dec 20 2009) ISSN: 2542-5641 [Electronic] China
• PMID: 20137504 (Publication Type: Journal Article, Review)

Chemical References

• Indoleamine-Pyrrole 2,3,-Dioxygenase

Topics

• Animals
• Gene Expression Regulation, Neoplastic (physiology)
• Humans
• Immune Tolerance (physiology)
• Indoleamine-Pyrrole 2,3,-Dioxygenase (metabolism)
• Neoplasms (enzymology, immunology)