[Association of ENA-78, IP-10 and VEGF gene polymorphism with idiopathic pulmonary fibrosis].

Abstract

OBJECTIVE:

To examine whether there was an association between epithelial neutrophil activating peptide 78 (ENA-78), interferon-inducible protein 10 (IP-10), vascular endothelial growth factor (VEGF) polymorphism and Chinese patients with idiopathic pulmonary fibrosis (IPF).

METHODS:

Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to analyze the gene polymorphisms of ENA-78 (-156G/C), IP-10 (-1596C/T) and VEGF (+405G/C) in 60 IPF patients and 60 controls with trauma or bone fracture matched in age, gender and smoking status.

RESULTS:

The distribution of carrying GC + CC genotype frequency (20.0%) and C allele frequency (12.7%) for ENA-78 in IPF patients was significantly higher than that in healthy controls [6.7% (P = 0.032) and 3.3% (P = 0.008), respectively], the relative risk of suffering from IPF of -156C allele gene carrier significantly increased (OR = 4.23, 95%CI: 1.35-13.20). The distribution of carrying CT + TT genotype frequency (10.0%) and T allele frequency (5.8%) for IP-10 in IPF patients was significantly lower than that in healthy controls [26.7% (P = 0.018) and 14.2% (P = 0.031), respectively], the relative risk of suffering from IPF of -1596T allele gene carrier decreased (OR = 0.38, 95%CI: 0.15-0.95). No association was found between VEGF (+405G/C) polymorphism and IPF.

CONCLUSIONS:

-156C allele for ENA-78 may be a risk factor of IPF and -1596T allele for IP-10 a beneficial factor of IPF. The VEGF (+405G/C) gene polymorphism has no effect upon the predisposition to IPF.

• Authors: Long Liu, Hua-Ping Dai, Bai Xiao, Shu Zhang, Cheng-Jun Ban, Ping Xin
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 89 Issue 38 Pg. 2690-4 (Oct 20 2009) ISSN: 0376-2491 [Print] China
• PMID: 20137269 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CXCL10 protein, human
• CXCL5 protein, human
• Chemokine CXCL10
• Chemokine CXCL5
• VEGFA protein, human
• Vascular Endothelial Growth Factor A

Topics

• Aged
• Aged, 80 and over
• Alleles
• Chemokine CXCL10 (genetics)
• Chemokine CXCL5 (genetics)
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Idiopathic Pulmonary Fibrosis (genetics)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Vascular Endothelial Growth Factor A (genetics)