A lipid-soluble red ginseng extract inhibits the growth of human lung tumor xenografts in nude mice.

Abstract

Lipid-soluble ginseng extract was prepared by n-hexane extraction of red ginseng. BALB/c-nu mice were inoculated with human lung cancer (NCI-H460) cells to establish a human tumor xenograft model in nude mice, and the lipid-soluble ginseng extract was orally administered. The tumor inhibitory rates of the lipid-soluble ginseng extract at doses of 0.1, 0.3, and 1.0 g/kg/day were 18.9% (P < .05), 60.0% (P < .001), and 67.5% (P < .001), respectively. The oral administration of the lipid-soluble extract of red ginseng showed a potent anticancer effect in nude mice bearing human lung cancer cells in a dose-dependent manner without any apparent toxicity. This lipid-soluble ginseng extract is a potential nontoxic anticancer supplement for the prevention and intervention of lung tumor growth through an oral administration route.

• Authors: Sung Dong Lee, Song-Kyu Park, Eun Sil Lee, Hwan Mook Kim, Chang Woo Lee, Kiho Lee, Ki Hoon Lee, Moo Rim Kang, Kwang Seung Lee, Junsoo Lee, Woo Ik Hwang, Dong Chung Kim
• Journal: Journal of medicinal food (J Med Food) Vol. 13 Issue 1 Pg. 1-5 (Feb 2010) ISSN: 1557-7600 [Electronic] United States
• PMID: 20136429 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Lipids
• Plant Extracts

Topics

• Animals
• Antineoplastic Agents, Phytogenic (pharmacology, therapeutic use)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Female
• Humans
• Lipids
• Lung Neoplasms (drug therapy)
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Panax
• Phytotherapy
• Plant Extracts (pharmacology, therapeutic use)
• Solubility
• Xenograft Model Antitumor Assays