HLA antigens in Italian multiple sclerosis patients.

Abstract

We analyzed HLA-A, -C, -B, -DR and -DQ specificities in 104 Italian multiple sclerosis patients and in 905 healthy controls. The frequencies of HLA-A23, A26, Cw4, DR3 and, especially DR5 antigens were significantly higher in multiple sclerosis patients than in controls. Patients with progressive course were characterized by high frequencies of B7, B8 and DR3 antigens: Cw1 and DRw11 shows a negative correlation with the extent of intrathecal IgG production. These data confirm that the HLA system may influence the clinical expression and the immune responses to the disease.

• Authors: L La Mantia, M T Illeni, C Milanese, A Salmaggi, M Eoli, G Pellegris, A Nespolo
• Journal: Italian journal of neurological sciences (Ital J Neurol Sci) Vol. 12 Issue 1 Pg. 81-6 (Feb 1991) ISSN: 0392-0461 [Print] Italy
• PMID: 2013528 (Publication Type: Journal Article)

Chemical References

• HLA Antigens
• HLA-A Antigens
• HLA-B Antigens
• HLA-C Antigens
• HLA-DQ Antigens
• HLA-DR Antigens
• Immunoglobulin G

Topics

• HLA Antigens (analysis)
• HLA-A Antigens (analysis)
• HLA-B Antigens (analysis)
• HLA-C Antigens (analysis)
• HLA-DQ Antigens (analysis)
• HLA-DR Antigens (analysis)
• Humans
• Immunoglobulin G (analysis)
• Italy
• Multiple Sclerosis (immunology)
• Reference Values