Protein-losing enteropathy and hypogammaglobulinaemia as first manifestations of disseminated histoplasmosis coincident with Nocardia infection.

Abstract

Disseminated histoplasmosis and nocardiosis typically affect immunocompromised hosts. We report a case of gastrointestinal and adrenal histoplasmosis, presenting as protein-losing enteropathy and hypogammaglobulinaemia, coincident with Nocardia infection, in a HIV-negative patient in whom a specific immunological defect could not be identified. Clinicians in areas of non-endemicity should be vigilant for rare manifestations of histoplasmosis.

• Authors: Jen Kok, Sharon C A Chen, Lyndal Anderson, Lucinda Berglund, Sue Sleiman, Alan Moss, Michael Bourke, David Fulcher, Nicole Gilroy
• Journal: Journal of medical microbiology (J Med Microbiol) Vol. 59 Issue Pt 5 Pg. 610-613 (May 2010) ISSN: 1473-5644 [Electronic] England
• PMID: 20133412 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Agammaglobulinemia (etiology)
• Endoscopy, Gastrointestinal
• Histoplasma (isolation & purification)
• Histoplasmosis (complications, diagnosis, pathology)
• Humans
• Jejunum (microbiology, pathology)
• Male
• Nocardia (isolation & purification)
• Nocardia Infections (complications, diagnosis, pathology)
• Protein-Losing Enteropathies (etiology)