Abstract |
A series of compounds of general formula [Ru(eta(6)-arene)(pta)(PR(3))Cl]BF(4) (arene = p-cymene or 4-phenyl-2- butanol; pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1] decane, PR(3) = PPh(2)(p-C(6)H(4)C(2)H(4)C(8)F(17)), PPh(p-C(6)H(4)C(2)H(4)C(8)F(17))(2), P(p-C(6)H(4)C(2)H(4)C(6)F(13))(3), PPh(3) or P(p-C(6)H(4)F)(3)) have been prepared and characterized by spectroscopic methods. The structure of [Ru(eta(6)- p-cymene)(pta)Cl(P(p-C(6)H(4)F)(3))]BF(4) has also been established in the solid state by X-ray crystallography. The cytotoxicities of the compounds were determined in the A2780 and A2780 cisplatin-resistant cell lines revealing that the fluorinated phosphines significantly increase antiproliferative activity relative to their bis- chloride precursors. Two of the complexes were found to be thermoresponsive, that is, showing poor water solubility at 37 degrees C and good solubility at 42 degrees C, the temperature of a heated tumor, providing a method of tumor targeting. Incubation at 42 degrees C for 2 h resulted in improved cytotoxicities for two of the complexes.
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Authors | Anna K Renfrew, Rosario Scopelliti, Paul J Dyson |
Journal | Inorganic chemistry
(Inorg Chem)
Vol. 49
Issue 5
Pg. 2239-46
(Mar 01 2010)
ISSN: 1520-510X [Electronic] United States |
PMID | 20131860
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Organometallic Compounds
- Phosphines
- Water
- Ruthenium
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Topics |
- Antineoplastic Agents
(chemistry, pharmacology, therapeutic use)
- Cell Line, Tumor
- Halogenation
- Hot Temperature
- Humans
- Inhibitory Concentration 50
- Neoplasms
(drug therapy, pathology)
- Organometallic Compounds
(chemistry, pharmacology, therapeutic use)
- Phosphines
(chemistry)
- Ruthenium
(chemistry)
- Solubility
- Water
(chemistry)
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