Encephalopathy resembling Creutzfeldt-Jakob disease following oral, prescribed doses of bismuth nitrate.

A patient given bismuth nitrate in the recommended dose range over 16 months developed panic attacks and a major depressive syndrome and, after 15 months, a myoclonic encephalopathy resembling Creutzfeldt-Jakob disease. He recovered four months after bismuth had been discontinued. Bismuth preparations are becoming popular in the treatment of gastritis; close attention to neurological and psychiatric symptoms seems mandatory.
AuthorsM J Von Bose, M Zaudig
JournalThe British journal of psychiatry : the journal of mental science (Br J Psychiatry) Vol. 158 Pg. 278-80 (Feb 1991) ISSN: 0007-1250 [Print] ENGLAND
PMID2012923 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Bismuth
  • Administration, Oral
  • Aged
  • Anxiety Disorders (chemically induced)
  • Bismuth (administration & dosage, adverse effects)
  • Creutzfeldt-Jakob Syndrome (chemically induced, diagnosis)
  • Depressive Disorder (chemically induced)
  • Diagnosis, Differential
  • Humans
  • Male
  • Panic
  • Substance-Related Disorders (diagnosis, etiology)

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