Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: KEY RESULTS: Treatment with dexamethasone suppressed joint swelling, hyperaemia and histological changes that include polymorphonuclear cell infiltration, synovial tissue proliferation and cartilage erosion in the arthritic rat knees. Treatment with RP67580 or AP7 plus CNQX did not attenuate hyperaemia or histological changes, but reduced joint allodynia and swelling. Co-administration of dexamethasone with these receptor antagonists produced greater inhibition on joint allodynia and swelling than their individual effects. CONCLUSIONS AND IMPLICATIONS:
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Authors | Francis F Y Lam, Ethel S K Ng |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 159
Issue 4
Pg. 958-69
(Feb 2010)
ISSN: 1476-5381 [Electronic] England |
PMID | 20128799
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Excitatory Amino Acid Antagonists
- Isoindoles
- Neurokinin-1 Receptor Antagonists
- Receptors, Glutamate
- Receptors, Neurokinin-1
- 7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one
- Substance P
- Glutamic Acid
- 6-Cyano-7-nitroquinoxaline-2,3-dione
- 2-Amino-5-phosphonovalerate
- Dexamethasone
- Freund's Adjuvant
- 2-amino-7-phosphonoheptanoic acid
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Topics |
- 2-Amino-5-phosphonovalerate
(analogs & derivatives, pharmacology)
- 6-Cyano-7-nitroquinoxaline-2,3-dione
(pharmacology)
- Animals
- Anti-Inflammatory Agents
(administration & dosage, pharmacology)
- Arthritis, Experimental
(chemically induced, drug therapy, metabolism, pathology)
- Dexamethasone
(administration & dosage, pharmacology)
- Drug Interactions
- Drug Therapy, Combination
- Excitatory Amino Acid Antagonists
(administration & dosage, pharmacology)
- Freund's Adjuvant
- Glutamic Acid
(metabolism)
- Injections, Intra-Articular
- Isoindoles
(pharmacology)
- Knee Joint
(drug effects, metabolism, pathology, physiopathology)
- Neurokinin-1 Receptor Antagonists
- Rats
- Rats, Sprague-Dawley
- Receptors, Glutamate
(drug effects, metabolism)
- Receptors, Neurokinin-1
(metabolism)
- Substance P
(metabolism)
- Time Factors
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