Abstract | OBJECTIVE: METHODS: RESULTS:
Fexofenadine induced a significant improvement in nasal and ocular symptoms (P < .001), nasal edema and secretion (P < .001), and nasal airway flow (P < .001). The clinical improvement was related to a significant reduction in all inflammatory mediators (P < .01 in all cases). CONCLUSION: This study demonstrates that fexofenadine is able to mediate significant changes in different nasal lavage markers from patients with intermittent allergic rhinitis. The changes observed in the markers analyzed in both nasal secretions and serum are attributable to the anti-inflammatory effects of fexofenadine in vivo.
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Authors | C Schäper, B Gustavus, B Koch, R Ewert, G Hanf, G Kunkel, O Noga, S Gläser |
Journal | Journal of investigational allergology & clinical immunology
(J Investig Allergol Clin Immunol)
Vol. 19
Issue 6
Pg. 459-64
( 2009)
ISSN: 1018-9068 [Print] Spain |
PMID | 20128420
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Antigens, Plant
- Inflammation Mediators
- Intercellular Adhesion Molecule-1
- Leukotriene D4
- Terfenadine
- Histamine
- fexofenadine
- Eosinophil Cationic Protein
- RNASE3 protein, human
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Topics |
- Adult
- Aged
- Anti-Inflammatory Agents
(administration & dosage, adverse effects)
- Antigens, Plant
(adverse effects, immunology)
- Artemisia
(immunology)
- Betula
(immunology)
- Disease Progression
- Eosinophil Cationic Protein
(analysis)
- Female
- Histamine
(analysis)
- Humans
- Inflammation Mediators
(analysis, immunology)
- Intercellular Adhesion Molecule-1
(analysis)
- Leukotriene D4
(analysis)
- Male
- Middle Aged
- Nasal Lavage Fluid
(chemistry, immunology)
- Pollen
(adverse effects, immunology)
- Rhinitis, Allergic, Seasonal
(drug therapy, immunology)
- Terfenadine
(administration & dosage, adverse effects, analogs & derivatives)
- Treatment Outcome
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